Table 4 : Principal Radiation Emission Data (>1%) Radiation /Emission Table 4, Table 5, and Table 6 display the principle radiation emission data, radiation attenuation by lead shielding, and physical decay of Ga 68. The prepared Ga 68 dotatate injection for intravenous use, is a sterile, pyrogen free, clear, colorless, buffered solution, with a pH -between 3.2 -3.8. Accessory cartridge contains: 660 mg porous silica.Īfter reconstitution and radiolabeling,, Ga 68 dotatate injection also contains hydrochloric acid as an excipient derived from the generator eluate.Vial 2 (buffer vial) contains: 60 mg formic acid 56.5 mg sodium hydroxide and water for injection. Vial 1 (reaction vial with lyophilized powder) contains: 40 mcg dotatate, 5 mcg 1, 10-phenanthroline 6 mcg gentisic acid 20 mg mannitol.NETSPOT is a Kit with the following components: (D)-Phenylalanyl-(L)Cysteinyl(L)-Tyrosyl-(D)-Tryptophanyl-(L)-Lysyl-(L)-Threoninyl-(L)-Cysteinyl-(L)- Threonine-cyclic(27)disulfide įigure 2 : Chemical Structure of dotatate Dotatate has a molecular weight of 1435.6 Daltons and its chemical structure is shown in Figure 2. The peptide has the amino acid sequence: H-D- Phe-Cys- Tyr-D- Trp-Lys-ThrCys- Thr-OH, and contains one disulfide bond. NETSPOT is supplied as a sterile, single-dose kit for preparation of Ga 68 dotatate injection for intravenous use.ĭotatate, also known as DOTA-0-Tyr3-Octreotate, is a cyclic 8 amino acid peptide with a covalently bound chelator (dota). You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Netspot. Tell the doctor if you have any side effect that bothers you or that does not go away. The most common side effects of Netspot include: Get medical help right away, if you have any of the symptoms listed above.
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